Tsiaj Cell Bioreactor

Tsiaj Cell Boreactor yog cov khoom siv tseem ceeb ntawm cov tsiaj txhu kab lis kev cai ntawm tsiaj cov tsiaj rau cov tsiaj txhu (piv txwv li cov tshuaj tiv thaiv kab mob cell, thiab lwm yam). Tsis zoo li microbial (piv txwv li cov kab mob, poov xab) bioreactors, tsiaj hlwb muaj kev nkag siab ntau ntxiv thiab yuav tsum tswj cov txheej txheem zoo nkauj thiab kab lis kev cai. Hauv qab no yog cov ntsiab lus tseem ceeb txog tsiaj cell bioreactor:

Biopharraceuticals

Kev tsim cov tshuaj monoclonal antibodies (piv txwv li cov tshuaj tiv thaiv rau kev kho mob qog noj ntshav), rechabbable cov tshuaj tiv thaiv (piv txwv li cov tshuaj hormones).

Tshuaj Tiv Thaiv Ntau Lawm

Piv txwv txhaj tshuaj tiv thaiv kab mob npaws, tshuaj tiv thaiv cov kaus mom (piv txwv li vero cell-raws cov tshuaj tiv thaiv cell).

Kev Kho Mob Ntawm Cell

Loj-teev nthuav dav ntawm tsheb-t hlwb, qia hlwb.

Tus mob vector ntau lawm

Adenovirus, Lentivirus, thiab lwm yam rau kev kho mob noob.

• Hom xov tooj: Muab faib ua cov lus qhia zoo (yuav tsum tau txuas rau hauv kev loj hlob saum npoo, xws li kev xaiv hlwb (xws li kev xaiv ib qho kev xaiv, HEK293).
• Ib puag ncig rhiab heev: Yuav Tsum Tswjhwm ntsuas kub (37 degree), pH (7. {{}, carbon dioxide concentration, shear zog, thiab lwm yam.
• Cov Tshuaj Noj Yuav Tsum Tau: Complex Nruab Nrab (muaj cov piam thaj, cov amino acids, ntshav qab zib lossis ntshav dawb dawb) yuav tsum muaj.
• Qeeb kev loj hlob: cov sij hawm sib npaug yog feem ntau 12-24 teev, ntau qeeb dua li cov microorganisms.

Stirred-Tank Bioractor

• Lub hauv paus ntsiab lus: sib xyaw thiab huab hwm coj hloov los ntawm cov neeg kho tshuab agitation (impeller), haum rau kev tshem tawm ntawm cell kev cai lij choj.
• Hom tau txais txiaj ntsig: paub tab, yooj yim rau nplai nce (muaj qib nce mus txog kaum txhiab ntawm litres).
• Kev sib tw: shear zog yuav ua rau cov hlwb ua phem, yuav tsum tau ua kom zoo sib xyaw ua ke nrawm thiab tsim kho kom zoo (piv txwv li siv qis qis shear paddles).

Tsau-txaj / puv-pw reactor

• Lub hauv paus ntsiab lus: cov cell yog txuas nrog tus qauv ruaj khov (piv txwv li, micrapharrier, fiber ntau cov kab ke.
• Qhov Zoo: High Cell Cell, Haum rau cov cells.
• Cov Kev Siv Cov Kev Siv: Ntau Lawm (piv txwv li Microcarrier-Raws Vero Cell Cature).

Hollow Fiber Reactor

• Lub hauv paus ntsiab lus: cov cells loj hlob ntawm sab nraud ntawm fiber ntau, qhov nruab nrab nruab nrab ntws sab hauv cov fiber, simulating ib puag ncig capillary hauv lub cev.
• Cov txiaj ntsig zoo: High Shet Cell, qis shear, haum rau cov khoom zais (piv txwv li cov tshuaj tiv thaiv).
• Cov Kev Siv: Kuaj qhov loj lossis me me sib ntaus.

• Lub cev tsis sib haum: kub, stirring ceev, yaj oxygen (ua), pH, pe-agon.
• Tshuaj Kev Lag Luam: concentration ntawm cov metabolites xws li piam thaj, lactate, ammonia, thiab lwm yam (ntawm on-linefile nrhiav).
• Roj ntsha: Lub zog ntawm tes (verobility), cov khoom lag luam (piv txwv li tshuaj tiv thaiv titer), metabolic flux kev tsom xam.
   

Cim npe nrov: Tsiaj Cell Bioreactor, Tuam Tshoj Tsiaj Cell Bienceactor Manufacturers, Lwm tus neeg, Hoobkas