Kev Ntsuam Xyuas Teeb Meem: Vim li cas nws nyuaj rau ntsuas qhov kev sojntsuam?
Hauv chav kuaj, ntxig ib qho ultrasonic sojntsuam rau hauv lub beaker siv cavitation kom ua tiav nano-dispersion, emulsification, lossis extraction. Kev ua haujlwm yog yooj yim thiab cov txiaj ntsig tau pom meej meej. Txawm li cas los xij, hom "batch processing" no ntsib peb lub fwj tseem ceeb thaum ntsuas:
1. Muaj peev xwm ua tau tsawg: Qhov kev sojntsuam qhov chaw siv tau raug txwv, thiab cov thawv loj loj - ntim tau yooj yim rau "ua cov chaw tuag," uas ua rau tsis zoo ib yam.
2. Qhov kub thiab txias: Kev sojntsuam yog nyob rau hauv kev sib cuag nrog cov khoom; Lub sijhawm ntev siab- lub zog ua haujlwm tau yooj yim tuaj yeem ua rau muaj kev kub ntxhov hauv cheeb tsam (ua kom sov- cov khoom rhiab heev) thiab hnav thiab detachment ntawm titanium alloy sojntsuam (hlau paug).
3. Tsis muaj peev xwm ua haujlwm tsis tu ncua: Nws yog qhov nyuaj rau kev koom ua ke nrog cov kav dej, cov kab ntau lawm ntawm kev lag luam niaj hnub, txwv tsis pub muaj peev xwm tso tawm.
Kev daws: Ua hauj lwm hauv paus ntsiab lus thiab qhov zoo ntawm ultrasonic txaus hlwb
Tus tsim logic ntawm ib qho ultrasonic flow cell yog "kom cov khoom ntws los ntawm lub suab teb," es tsis yog "kom cia lub suab teb nrhiav cov khoom." Nws cov qauv tseem ceeb feem ntau muaj xws li ultrasonic transducer, ntws channel kab noj hniav, thiab kub -tswj tsho.
Cov txiaj ntsig tseem ceebpiv rau txoj kev sojntsuam:
1. Nruam Hauv - Txheej Txheem (CIP): Cov ntaub ntawv nthuav dav hauv kab noj hniav hauv qab lub twj tso kua mis, ua rau kev ua haujlwm 24-teev tsis cuam tshuam thiab ua kom muaj peev xwm ntau lawm.
2. Homogenized ua: Los ntawm optimized flow channel tsim (xws li vortex flow channels), nws xyuas kom meej tias txhua qhov poob ntawm cov khoom dhau los ntawm lub suab nrov ntawm tib qhov kev siv, tswj cov batch CV (coefficient ntawm variation) mus rau hauv 5%.
3.Kev huv huv thiab ntsuas kub: Siv 316L stainless hlau lossis iav kab noj hniav, ua ke nrog lub tsho txias sab nraud, tshem tawm cov hlau tsis huv thiab tswj cov txheej txheem kub (tshwj xeeb yog qhov tseem ceeb rau cov cua sov- cov ntaub ntawv rhiab heev xws li liposomes thiab probiotics).
|
|
Traditional sojntsuam hom (intermittent) |
Ultrasonic flow cell (nruam) |
|
Txoj kev tuav |
Batch processing yuav tsum rov thauj khoom thiab tshem tawm. |
Kev pub noj tsis tu ncua thiab tso tawm, haum rau kev ua haujlwm 24-teev. |
|
Kev tsis sib xws |
Lub zog gradient muaj nyob, ua rau muaj qhov sib txawv tseem ceeb ntawm cov nyhuv hauv qab thiab sab saum toj ntawm lub tank. |
Tag nrho cov ntaub ntawv ntws los ntawm tib lub siab -zog lub zog, ua rau muaj qhov sib xws. |
|
Kev tswj qhov kub thiab txias |
Kev pheej hmoo siab ntawm kev kub ntxhov hauv cheeb tsam thiab nyuaj rau kev tswj qhov kub thiab txias |
Nrog lub tsho txias, qhov kub thiab txias yog tswj tau heev. |
|
Kev phom sij |
Kev sojntsuam los rau hauv kev sib cuag ncaj qha nrog cov khoom, ua rau muaj kev pheej hmoo ntawm hnav thiab detachment. |
Optional contactless tsim (xws li ib tug spacer) rau xoom muaj kuab paug |
|
Amplification Logic |
Nws yog ib qho nyuaj rau scale li linearly (raws li ntim nce, lub zog ceev txo). |
Lub peev xwm tuaj yeem nce ntxiv los ntawm kev ncua sijhawm ua haujlwm lossis los ntawm kev ua haujlwm sib luag. |
Kev Tshawb Fawb Cov Neeg Siv Khoom: Kev lees paub los ntawm "Kev xav" mus rau "kev tsim khoom tiag tiag"
Case 1:Lub Tuam Txhab Pharmaceutical (Oceania) - Tsawg-Tsuas Kub, Siab-Kev Ua Haujlwm Zoo ntawm Polyphenolic Active Cov Khoom Siv
Keeb kwm:Lub tuam txhab pib tincture tau txhawj xeeb txog cov nqi rho tawm tsawg (kwv yees li 60%), degradation ntawm tshav kub- cov khoom rhiab heev vim qhov kub thiab txias, thiab kev siv hnyav hnyav thaum ua cov nplooj ntoo.
Kev daws:Lub UFC-300 series huv ultrasonic ndlwg ntawm tes tau muab tso rau hauv cov txheej txheem kev npaj tshuaj uas twb muaj lawm. Cov khoom yog pumped thiab circulated los ntawm ib tug ultrasonic teb, nrog ib tug kub tswj ntau yam ntawm 20-80℃(qhov tseeb ± 0.5 degree), tsis tu ncua tswj ntawm 56 degree.
Cov txiaj ntsig:
Extraction Efficiency: Lub sij hawm Extraction raug txo los ntawm 4 teev mus rau 30 feeb, thiab cov extraction tus nqi ntawm cov khoom xyaw nquag tau nce mus rau ntau dua 92%.
Active Ingredient Retention: Under low-temperature conditions, the retention rate of heat-sensitive components such as polyphenols was >98%.
Solvent Recovery: Qhov kaw - lub voj voog ncig tau nce qhov hnyav rov qab mus rau ntau dua 90%, ua tau raws li GMP ntsuab cov cai.
Case 2:Lub tuam txhab ua zaub mov (Southwest Europe) - Homogenization thiab ruaj khov txhim kho ntawm Soy Mis / Nroj Tsuag Protein Emulsion
Keeb kwm:Cov kua mis uas tsim los ntawm cov nroj tsuag -raws li lub koom haum haus dej haus pom cov roj- dej sib cais tom qab ib lub lim tiam ntawm kev cia. Cov txheej txheem qub (colloidal mill) tsis txaus kho cov protein ntau, thiab siab -kub, ntev- lub sij hawm shearing ua rau cov protein denaturation.
Kev daws:Ib qho zaub mov-qib ultrasonic ntws- los ntawm lub tank tau ntxiv ua homogenization hauv online ua ntej pasteurization. Cov nyhuv cavitation tau siv los tsim cov microjets uas rhuav tshem cov roj globules thiab cov protein ntau.
Cov txiaj ntsig:
Particle Loj Tswjhwm: Qhov loj me me ntawm emulsion roj tee dej / cov khoom noj protein txo qis ntawm 1.5μm mus rau qis dua 0.8μm, txhim kho cov khoom txee- lub neej ruaj khov los ntawm 50%.
Saj thiab khoom noj khoom haus: High-kub denaturation raug zam, ua rau lub saj smoother thiab ua tiav kev khaws cia ntawm cov protein ua haujlwm.
Nruam ua: Nruam homogenization tau tiav thoob plaws hauv tag nrho cov txheej txheem los ntawm raw cov ntaub ntawv mus sau, ua kom muaj peev xwm ntau lawm los ntawm 3 zaug.
Kev xaiv yam: Cov lus pom zoo
Xaiv qhov ntws- ntawm tes tsis yog qhov yooj yim ntawm "lub zog sib piv"; cov nram qab no engineering parameters yuav tsum tau txiav txim siab:
1. Flow rate thiab chamber ntim:Xam lub sij hawm nyob rau hauv raws li lub sij hawm throughput (L / h) thiab cov khoom viscosity kom paub meej tias cov khoom yog txaus rau kev kho mob ultrasonic.
2. Khoom siv:Nyob rau hauv ib puag ncig uas muaj zog acids, muaj zog alkalis, los yog siab - ntsev cov kuab tshuaj, corrosion kuj ntawm cov khoom sealing (xws li, PTFE, EPDM) thiab chamber (titanium alloy / 316L / Hastelloy alloy) yuav tsum tau lees paub.
3. Kev tswj qhov kub thiab txias:Rau cov cua sov- cov ntaub ntawv rhiab heev, cov khoom siv hluav taws xob sib hloov ntawm lub tsho yuav tsum raug suav kom tiv thaiv kom tsis txhob muaj qhov kub thiab txias ntau dhau vim muaj qhov cuam tshuam cavitation.
4. System integration:Kev khiav-los ntawm lub xovtooj yuav tsum ua haujlwm nrog lub twj tso kua mis peristaltic / centrifugal twj tso kua mis, lub tank cia, thiab PLC tswj qhov system. Nws raug nquahu kom ua qhov tseem ceeb rau cov neeg muag khoom uas muab cov txheej txheem ua tiav rau tag nrho cov kab ntau lawm.
Ultrasonic flow cell tsis yog ib qho "pipeline + sojntsuam," tab sis ib qho kev ua haujlwm engineering uas koom nrogacoustic field design, fluid dynamics simulation, thiab cov ntaub ntawv science. Rau cov neeg siv npaj yuav hloov los ntawm "intermittent" mus rau "nruam", xaiv cov chaw tsim khoom nrogkua simulation muaj peev xwmthiab adatabase ntawm tiag -world applicationsyog qhov tseem ceeb. Peb pom zoo kom uame - ntsuas ntsuas ntsuasua ntej pib qhov project, siv cov ntaub ntawv xws li particle loj tsom xam thiab scanning electron microscopy los xyuas qhov sib xws ntawm cov khoom siv thiab cov ntaub ntawv, kom ntseeg tau tias muaj kev vam meej rau cov txheej txheem teev- nce.